The report features insights from the Health-ISAC Ransomware Events Database, Indicator Sharing program, Physical Security, and Targeted Alerts initiative, showcasing the community-felt impacts of major threats to the global health sector in 2025. The report features data-driven insights from the Health-ISAC Ransomware Events Database, Physical Security assessments, and the Targeted Alerts initiative, which distributed more than 1,200 warnings to the sector in 2025. These findings showcase the community-felt impacts of major threats, including the rise of AI-driven attacks and significant supply chain vulnerabilities.